High-Speed Nanosecond Imaging Captures Shock Wave Passing Through Single Cell

A significant advancement in nanosecond photography has facilitated the observation of a microscopic shock wave passing through a single biological cell. This remarkable achievement was made possible by a novel photography technique employing ultrafast electronic cameras capable of capturing images at the speed of one billionth of a second.

The team, led by researchers at the University of Tokyo, has developed a system known as spectrum circuit, effectively bridging the gap between optical imaging and conventional electronic cameras. This innovation allows photography at ultrafast speeds with minimal blur and enhanced accuracy, providing unprecedented insight into high-speed biological processes.

According to Takao Saiki, a doctoral student from the Department of Precision Engineering at the University of Tokyo, this breakthrough has enabled the observation, for the first time in history, of the interaction between a shock wave and a biological cell. The shock wave’s velocity inside the cell was found to be faster than outside the cell, signifying a significant advancement in our comprehension of cellular dynamics.

The development of precision optical circuitry, known as spectrum circuit, has played a pivotal role in capturing clear images of cells without impacting their structure or causing damage. This, in conjunction with the existing single-shot optical imaging technique called sequentially timed all-optical mapping photography, has provided scientists with a powerful tool for visualizing high-speed biological processes with unparalleled clarity.

This technology has far-reaching implications beyond capturing shock waves passing through cells. The researchers also utilized it to observe the effects of laser ablation on glass, shedding light on the interplay between different physical processes over picoseconds, nanoseconds, and milliseconds. This has significant implications for applications in both industry and medicine.

The team aims to further develop this imaging technique to visualize how cells interact with acoustic waves, such as those used in ultrasound and shock wave therapy. Additionally, they are exploring ways to leverage their technology to enhance manufacturing processes, with the objective of achieving faster, more precise, and more cost-effective production.

Keiichi Nakagawa, an associate professor from the Department of Bioengineering and the Department of Precision Engineering at the University of Tokyo, expressed the team’s enthusiasm for the potential applications of their groundbreaking technology, stating: “We expect to make broad contributions in various fields, from biomedicine to manufacturing, materials, the environment, and energy.”

In summary, the development of nanosecond photography technology represents a significant leap forward in our ability to capture and understand high-speed biological processes. This breakthrough opens the door to new possibilities for scientific research and technological advancements across diverse fields.